Small. Fast. Reliable.
Choose any three.
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  _While connections to on-disk databases should not be carried across a Unix fork(), is there any reason not to do it with an in-memory database?_
  (2003-10-21 by drh:) Not that I know of.
+ 
+ DK: Of course, when you do the fork() you are creating a new copy of the in-memory db for the child process. So subsequent edits to the db in the child won't show up in the parents copy, and vice-versa.