Small. Fast. Reliable.
Choose any three.
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  By the way, at a lower level you will find that the operating system already intelligently caches disk sectors that are being accessed regularly. Even though the database server itself would probably outperform the underlying OS in knowing how and what exactly to cache, the underlying caching by the OS already contributes substantially to improving SQLite's performance under high concurrency.
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+ What about multi-tier usage? Anybody had success using it from appservers? (By what I read I guess it should work pretty well there).